Bone pathology can be challenging because the skeleton is a living tissue prone to developing a diverse array of inflammatory, metabolic, genetic, reactive, circulatory, and neoplastic abnormalities. Several areas of bone pathology are particularly difficult or problematic for hematopathologists given the close resemblance of some hematologic entities to primary/metastatic bone lesions; examples include plasmacytic disorders versus osteoblastic tumors and lymphoma/leukemia versus round cell tumors of bone. This article provides a conceptual and practical overview of selective bone disorders commonly encountered in the differential diagnosis of hematologic diseases.
Keywords: Ewing sarcoma; Langerhans cell histiocytosis; Mastocytosis; Mesenchymal chondrosarcoma; Osteomyelitis; Osteosarcoma; Plasmacytoma; Rosai-Dorfman disease.
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