Trend level gene-gender interaction effect for the BDNF rs6265 variant on age of onset of psychosis

Rohit J Lodhi; Yabing Wang; Georgina Macintyre; Candice Crocker; Alexandra Loverock; Beatriz Carvalho Henriques; Brodie Heywood; Sudhakar Sivapalan; Alexandra Bowker; Brett Majeau; Carol Bolt; Darren Bugbee; Virginia Newton; Philip Tibbo; Scot E Purdon; Katherine J Aitchison

doi:10.1016/j.psychres.2019.112500

Trend level gene-gender interaction effect for the BDNF rs6265 variant on age of onset of psychosis

Psychiatry Res. 2019 Oct:280:112500. doi: 10.1016/j.psychres.2019.112500. Epub 2019 Aug 8.

Authors

Rohit J Lodhi¹, Yabing Wang¹, Georgina Macintyre², Candice Crocker³, Alexandra Loverock⁴, Beatriz Carvalho Henriques¹, Brodie Heywood¹, Sudhakar Sivapalan¹, Alexandra Bowker⁴, Brett Majeau⁴, Carol Bolt⁴, Darren Bugbee⁵, Virginia Newton⁴, Philip Tibbo⁶, Scot E Purdon⁷, Katherine J Aitchison⁸

Affiliations

¹ Department of Psychiatry and Medical Genetics, University of Alberta, Edmonton, AB, Canada.
² Department of Medicine, University of Alberta, Edmonton, AB, Canada.
³ Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
⁴ Neuropsychology Department, Alberta Hospital Edmonton, AB, Canada.
⁵ Department of Family Medicine, University of Alberta, Edmonton, AB, Canada.
⁶ Department of Psychiatry, Dalhousie University, Halifax, NS, Canada; Nova Scotia Early Psychosis Program, Halifax, NS, Canada.
⁷ Neuropsychology Department, Alberta Hospital Edmonton, AB, Canada; Edmonton Early Intervention in Psychosis Clinic, Edmonton, AB, Canada.
⁸ Department of Psychiatry and Medical Genetics, University of Alberta, Edmonton, AB, Canada; Edmonton Early Intervention in Psychosis Clinic, Edmonton, AB, Canada. Electronic address: kaitchis@ualberta.ca.

PMID: 31445421
DOI: 10.1016/j.psychres.2019.112500

Abstract

A BDNF rs6265 [A/A] by gender by cannabis use interaction has been associated with age of onset of psychosis (AoP). We examined the gender and cannabis use-adjusted association between BDNF rs6265 [G>A] and AKT1 rs2494732 [T>C] and AoP. Data from 167 Caucasians on AoP and age at first regular cannabis use were collected. Kaplan-Meier and Cox regression analyses were conducted. A trend level gene-gender interaction effect was observed for the BDNF rs6265 A/A genotype, controlling for age at first regular cannabis use. Larger collaborative research projects are required to further investigate this effect.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Age of Onset
Brain-Derived Neurotrophic Factor / genetics*
Epistasis, Genetic / genetics*
Female
Genetic Variation / genetics*
Humans
Male
Marijuana Smoking / adverse effects
Marijuana Smoking / genetics*
Marijuana Smoking / psychology
Polymorphism, Single Nucleotide / genetics
Psychoses, Substance-Induced / diagnosis
Psychoses, Substance-Induced / genetics*
Psychoses, Substance-Induced / psychology
Sex Characteristics*
Young Adult

Substances

Brain-Derived Neurotrophic Factor
BDNF protein, human

Grants and funding

200810 /CIHR/Canada