Abstract
Advances in the understanding of the Tribbles family of pseudokinases (TRIB1, TRIB2 and TRIB3) reveal these proteins as potentially valuable biomarkers of disease diagnosis, prognosis, prediction and clinical strategy. In their role as signalling mediators and scaffolding proteins, TRIBs lead to changes in protein stability and activity, which impact on diverse cellular processes such as proliferation, differentiation, cell cycle and cell death. We review the role of TRIB proteins as promising therapeutic targets, with an emphasis on their role in cancer, and as biomarkers, with potential application across diverse pathological processes.
Keywords:
TRIB; biomarker; cancer; drug targeting; pseudokinase.
© 2019 Federation of European Biochemical Societies.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Biomarkers, Tumor / metabolism*
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Calcium-Calmodulin-Dependent Protein Kinases / metabolism*
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Cell Cycle
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Cell Cycle Proteins / metabolism*
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Cell Death
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Cell Differentiation
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Cell Proliferation
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Humans
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Intracellular Signaling Peptides and Proteins / metabolism*
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Neoplasms / diagnosis*
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Neoplasms / metabolism
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Protein Serine-Threonine Kinases / antagonists & inhibitors*
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Protein Serine-Threonine Kinases / metabolism
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Repressor Proteins / metabolism*
Substances
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Biomarkers, Tumor
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Cell Cycle Proteins
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Intracellular Signaling Peptides and Proteins
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Repressor Proteins
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TRIB1 protein, human
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TRIB3 protein, human
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Protein Serine-Threonine Kinases
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Calcium-Calmodulin-Dependent Protein Kinases
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TRIB2 protein, human