Nomenclature report for killer-cell immunoglobulin-like receptors (KIR) in macaque species: new genes/alleles, renaming recombinant entities and IPD-NHKIR updates

Jesse Bruijnesteijn; Natasja G de Groot; Nel Otting; Giuseppe Maccari; Lisbeth A Guethlein; James Robinson; Steven G E Marsh; Lutz Walter; David H O'Connor; John A Hammond; Peter Parham; Ronald E Bontrop

doi:10.1007/s00251-019-01135-8

Nomenclature report for killer-cell immunoglobulin-like receptors (KIR) in macaque species: new genes/alleles, renaming recombinant entities and IPD-NHKIR updates

Immunogenetics. 2020 Feb;72(1-2):37-47. doi: 10.1007/s00251-019-01135-8. Epub 2019 Nov 29.

Authors

Jesse Bruijnesteijn¹, Natasja G de Groot², Nel Otting², Giuseppe Maccari^{3

4}, Lisbeth A Guethlein⁵, James Robinson^{4

6}, Steven G E Marsh^{4

6}, Lutz Walter⁷, David H O'Connor⁸, John A Hammond³, Peter Parham⁵, Ronald E Bontrop^{2

9}

Affiliations

¹ Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288, GJ, Rijswijk, The Netherlands. bruijnesteijn@bprc.nl.
² Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288, GJ, Rijswijk, The Netherlands.
³ The Pirbright Institute, Pirbright, Woking, Surrey, UK.
⁴ Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London, NW3 2QG, UK.
⁵ Department of Structural Biology and Department of Microbiology and Immunology, Stanford University, Stanford, CA, 94305, USA.
⁶ UCL Cancer Institute, University College London, Royal Free Campus, Pond Street, Hampstead, London, NW3 2QG, UK.
⁷ Primate Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, 37077, Göttingen, Germany.
⁸ Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, 53711, USA.
⁹ Utrecht University, Theoretical Biology and Bioinformatics, 3584, CH, Utrecht, The Netherlands.

PMID: 31781789
DOI: 10.1007/s00251-019-01135-8

Abstract

The Killer-cell Immunoglobulin-like Receptors (KIR) are encoded by a diverse group of genes, which are characterized by allelic polymorphism, gene duplications, and recombinations, which may generate recombinant entities. The number of reported macaque KIR sequences is steadily increasing, and these data illustrate a gene system that may match or exceed the complexity of the human KIR cluster. This report lists the names of quality controlled and annotated KIR genes/alleles with all the relevant references for two different macaque species: rhesus and cynomolgus macaques. Numerous recombinant KIR genes in these species necessitate a revision of some of the earlier-published nomenclature guidelines. In addition, this report summarizes the latest information on the Immuno Polymorphism Database (IPD)-NHKIR Database, which contains annotated KIR sequences from four non-human primate species.

Keywords: Cynomolgus; Killer-cell immunoglobulin-like receptors; Macaque species; Nomenclature; Recombinants; Rhesus.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Databases, Factual*
Immunogenetics*
Macaca mulatta / genetics*
Polymorphism, Genetic*
Receptors, KIR / genetics*
Receptors, KIR / immunology*
Terminology as Topic*

Substances

Receptors, KIR

Abstract

Publication types

MeSH terms

Substances

Grants and funding