Osteopontin-c is overexpressed in KMT2A-AFF1 positive pediatric B-cell lymphoblastic leukemia when compared to those with ETV6-RUNX1"

Leuk Res. 2020 Apr:91:106316. doi: 10.1016/j.leukres.2020.106316. Epub 2020 Feb 27.

Authors

Ana Clara Santos da Fonseca Bastos¹, Abigail Cristina da Silva Rezende¹, Luciana Bueno Ferreira¹, Caroline Barbieri Blunck², Maria S Pombo-de-Oliveira³, Mariana Emerenciano², Etel Rodrigues Pereira Gimba⁴

Affiliations

¹ Cellular and Molecular Oncobiology Program, Research Centre, Instituto Nacional de Câncer-INCA, Rio de Janeiro, RJ, Brazil.
² Division of Clinical Research, Research Centre, Instituto Nacional de Câncer-INCA, Rio de Janeiro, RJ, Brazil.
³ Paediatric Haematology-Oncology Program, Research Centre, Instituto Nacional de Câncer-INCA, Rio de Janeiro, RJ, Brazil.
⁴ Cellular and Molecular Oncobiology Program, Research Centre, Instituto Nacional de Câncer-INCA, Rio de Janeiro, RJ, Brazil; Department of Natural Sciences, Universidade Federal Fluminense, Rio das Ostras, RJ, Brazil. Electronic address: etelgimba@id.uff.br.

PMID: 32114371
DOI: 10.1016/j.leukres.2020.106316

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Alternative Splicing
B-Lymphocytes / metabolism
B-Lymphocytes / pathology
Biomarkers, Tumor / genetics
Biomarkers, Tumor / metabolism
Child
Child, Preschool
Core Binding Factor Alpha 2 Subunit / genetics*
Core Binding Factor Alpha 2 Subunit / metabolism
DNA-Binding Proteins / genetics*
DNA-Binding Proteins / metabolism
Female
Gene Expression Regulation, Leukemic*
Histone-Lysine N-Methyltransferase / genetics*
Histone-Lysine N-Methyltransferase / metabolism
Humans
Infant
Male
Myeloid-Lymphoid Leukemia Protein / genetics*
Myeloid-Lymphoid Leukemia Protein / metabolism
Oncogene Proteins, Fusion / genetics*
Oncogene Proteins, Fusion / metabolism
Osteopontin / antagonists & inhibitors
Osteopontin / genetics*
Osteopontin / metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
Prognosis
Protein Isoforms / antagonists & inhibitors
Protein Isoforms / genetics
Protein Isoforms / metabolism
RNA, Small Interfering / genetics
RNA, Small Interfering / metabolism
Risk Factors
Transcriptional Elongation Factors / genetics*
Transcriptional Elongation Factors / metabolism

Substances

Biomarkers, Tumor
Core Binding Factor Alpha 2 Subunit
DNA-Binding Proteins
KMT2A protein, human
Oncogene Proteins, Fusion
Protein Isoforms
RNA, Small Interfering
SPP1 protein, human
TEL-AML1 fusion protein
Transcriptional Elongation Factors
Osteopontin
Myeloid-Lymphoid Leukemia Protein
AFF1 protein, human
Histone-Lysine N-Methyltransferase