Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development

Affiliations

• ¹ Institute of Pediatrics, Children's Hospital of Fudan University and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and metabolism, Ministry of Science and technology and Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, 200032, China.
• ² Center of Assisted Reproduction, Shanghai East hospital, Tongji University, Shanghai, 200120, China.
• ³ The Reproductive Medical Center of Xiangya Hospital, Central South University, Changsha, 41008, China.
• ⁴ Reproductive Medicine Center, Shaanxi Maternal and Child Care Service Center, Xi'an, 710069, China.
• ⁵ NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, 200032, China.
• ⁶ Reproductive Medicine Center, Shanghai Ninth Hospital, Shanghai Jiao Tong University, Shanghai, 200011, China.
• ⁷ Shanghai Ji Ai Genetics and IVF Institute, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, China.
• ⁸ Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China.
• ⁹ Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200030, China.
• ¹⁰ State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, 200438, China.
• ¹¹ Institute of Pediatrics, Children's Hospital of Fudan University and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and metabolism, Ministry of Science and technology and Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, 200032, China. wangleiwanglei@fudan.edu.cn.
• ¹² Zhuhai Fudan Innovation Institute, Zhuhai, 519000, China. wangleiwanglei@fudan.edu.cn.
• ¹³ Shanghai Center for Women and Children's Health, Shanghai, 200062, China. wangleiwanglei@fudan.edu.cn.
• ¹⁴ Institute of Pediatrics, Children's Hospital of Fudan University and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and metabolism, Ministry of Science and technology and Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, 200032, China. sangqing@fudan.edu.cn.
• ¹⁵ Zhuhai Fudan Innovation Institute, Zhuhai, 519000, China. sangqing@fudan.edu.cn.