Multiple Endocrine Neoplasia: Spectrum of Abdominal Manifestations

AJR Am J Roentgenol. 2020 Oct;215(4):885-895. doi: 10.2214/AJR.19.22542. Epub 2020 Jul 13.

Abstract

OBJECTIVE. Multiple endocrine neoplasia (MEN) syndromes are autosomal-dominant genetic disorders that predispose two or more organs of the endocrine system to tumor development. Although the diagnosis relies on clinical and serologic findings, imaging provides critical information for surgical management with the ultimate goal of complete tumor resection. CONCLUSION. This article reviews abdominal neoplasms associated with the various subtypes of MEN syndromes, with a focus on clinical presentation and characteristic imaging features.

Keywords: Zollinger-Ellison syndrome; gastrinoma; insulinoma; multiple endocrine neoplasia; pancreatic endocrine tumor; somatostatinoma.

Publication types

  • Review

MeSH terms

  • Abdominal Neoplasms / diagnostic imaging*
  • Abdominal Neoplasms / pathology
  • Humans
  • Multiple Endocrine Neoplasia / diagnostic imaging*
  • Multiple Endocrine Neoplasia / pathology
  • Radiography, Abdominal