IRP2-Hif1α/Hif2α signaling: a novel mechanism of metabolic switch from aerobic glycolysis to oxidative phosphorylation

Acta Biochim Biophys Sin (Shanghai). 2020 Oct 19;52(10):1175-1177. doi: 10.1093/abbs/gmaa088.

Authors

Li Zhu¹, Qionglin Zhou¹, Lu He², Linxi Chen¹

Affiliations

¹ Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China.
² Department of Pharmacy, The First Affiliated Hospital, University of South China, Hengyang 421001, China.

PMID: 32813008
DOI: 10.1093/abbs/gmaa088

No abstract available

MeSH terms

Animals
Basic Helix-Loop-Helix Transcription Factors / genetics
Basic Helix-Loop-Helix Transcription Factors / metabolism*
Glycolysis*
Humans
Hypoxia-Inducible Factor 1, alpha Subunit / genetics
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism*
Iron Regulatory Protein 2 / genetics
Iron Regulatory Protein 2 / metabolism*
Oxidative Phosphorylation*
Signal Transduction*

Substances

Basic Helix-Loop-Helix Transcription Factors
HIF1A protein, human
Hypoxia-Inducible Factor 1, alpha Subunit
endothelial PAS domain-containing protein 1
IREB2 protein, human
Iron Regulatory Protein 2