Herpes simplex keratitis (HSK) is a common, potentially blinding condition characterised by recurrent infections of the cornea, seen by both general ophthalmologists and corneal specialists. Successful treatment of recurrences reduces disease duration, prevents progressive corneal scaring leading to vision loss and reduces risk of further recurrences. In this review we discuss the relative advantages of the diagnostic laboratory investigations including polymerase chain reaction, viral culture and fluorescence-based immunohistochemistry. We review treatment strategies in selected aspects of HSK and discuss the management options in cases not responding to treatment.
摘要: 单纯疱疹病毒性角膜炎(herpes simplex keratitis, HSK) 是一种常见、潜在的致盲性疾病, 其特征是角膜反复感染, 普通眼科医生和角膜专家都可见到该病。成功治疗其反复发作可缩短病程, 防止进行性角膜瘢痕形成所导致的视力丧失以及降低进一步复发的风险。在这篇综述中, 我们讨论了实验室诊断包括聚合酶链反应、病毒培养及基于荧光的免疫组化的相对优势。我们对HSK在某些方面的治疗策略进行了回顾, 以及针对治疗无效病例的处理方案。.