Early decrease in intermediate monocytes in peripheral blood is characteristic of multiple system atrophy-cerebellar type

Dai Matsuse; Ryo Yamasaki; Guzailiayi Maimaitijiang; Hiroo Yamaguchi; Katsuhisa Masaki; Noriko Isobe; Takuya Matsushita; Jun-Ichi Kira

doi:10.1016/j.jneuroim.2020.577395

Early decrease in intermediate monocytes in peripheral blood is characteristic of multiple system atrophy-cerebellar type

J Neuroimmunol. 2020 Dec 15:349:577395. doi: 10.1016/j.jneuroim.2020.577395. Epub 2020 Sep 20.

Authors

Dai Matsuse¹, Ryo Yamasaki², Guzailiayi Maimaitijiang³, Hiroo Yamaguchi⁴, Katsuhisa Masaki⁵, Noriko Isobe⁶, Takuya Matsushita⁷, Jun-Ichi Kira⁸

Affiliations

¹ Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: matsuse@neuro.med.kyushu-u.ac.jp.
² Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: ryoya@neuro.med.kyushu-u.ac.jp.
³ Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: maimai@neuro.med.kyushu-u.ac.jp.
⁴ Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: yhiroo@neuro.med.kyushu-u.ac.jp.
⁵ Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
⁶ Department of Neurological Therapeutics, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: kuroki@neuro.med.kyushu-u.ac.jp.
⁷ Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: matusita@neuro.med.kyushu-u.ac.jp.
⁸ Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan; Translational Neuroscience Center, Graduate School of Medicine, and School of Pharmacy at Fukuoka, International University of Health and Welfare, 137-1 Enokizu, Ookawa, Fukuoka 831-8501, Japan; Department of Neurology, Brain and Nerve Center, Fukuoka Central Hospital, International University of Health and Welfare, 2-6-11 Yakuin, Chuou-ku, Fukuoka 810-0022, Japan. Electronic address: kira@neuro.med.kyushu-u.ac.jp.

PMID: 32977251
DOI: 10.1016/j.jneuroim.2020.577395

Abstract

To identify biomarkers for multiple system atrophy-cerebellar type (MSA-C), we used flow cytometry to measure surface marker expression of peripheral blood monocytes from patients with MSA-C or hereditary spinocerebellar degeneration (hSCD) and from healthy controls (HCs). The percentage of intermediate monocytes was significantly lower in MSA-C patients than in hSCD patients and HCs and showed significant positive correlations with disease duration and unified MSA rating scale scores. The percentage of CD62L⁺ intermediate monocytes was significantly lower in MSA-C patients than in hSCD patients and HCs. Early decrease of peripheral blood intermediate monocytes is characteristic of MSA-C and is a biomarker.

Keywords: Biomarker; Intermediate monocyte; Monocyte; Multiple system atrophy; Surface marker.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Cerebellum / metabolism*
Cerebellum / pathology*
Female
Humans
Leukocytes, Mononuclear / metabolism
Male
Middle Aged
Monocytes / metabolism*
Multiple System Atrophy / blood*
Multiple System Atrophy / diagnosis*
Olivopontocerebellar Atrophies / blood
Olivopontocerebellar Atrophies / diagnosis