Senescent bone marrow microenvironment promotes Nras-mutant leukemia

Peiqing Zhou; Chengxiang Xia; Tongjie Wang; Yong Dong; Qitong Weng; Xiaofei Liu; Yang Geng; Jinyong Wang; Juan Du

doi:10.1093/jmcb/mjaa062

Senescent bone marrow microenvironment promotes Nras-mutant leukemia

J Mol Cell Biol. 2021 Apr 10;13(1):72-74. doi: 10.1093/jmcb/mjaa062.

Authors

Peiqing Zhou^{1

2

3

4}, Chengxiang Xia^{1

3

4}, Tongjie Wang⁵, Yong Dong¹, Qitong Weng^{1

2}, Xiaofei Liu¹, Yang Geng¹, Jinyong Wang^{1

2

3

4

5}, Juan Du^{1

2

3

4}

Affiliations

¹ CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
² University of Chinese Academy of Sciences, Beijing 100049, China.
³ Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
⁴ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
⁵ Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou 510005, China.

No abstract available

Publication types

Letter

MeSH terms

Animals
Bone Marrow / pathology
Cellular Senescence / genetics*
Disease Models, Animal
Humans
Leukemia / genetics*
Leukemia / pathology
Mesenchymal Stem Cells / pathology*
Mice
Monomeric GTP-Binding Proteins / genetics*
Mutation
Tumor Microenvironment / genetics*

Substances

Monomeric GTP-Binding Proteins
Nras protein, mouse