Leukemic cells expressing NCOR1-LYN are sensitive to dasatinib in vivo in a patient-derived xenograft mouse model

Leukemia. 2021 Jul;35(7):2092-2096. doi: 10.1038/s41375-020-01091-3. Epub 2020 Nov 16.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Dasatinib / pharmacology*
  • Disease Models, Animal
  • Heterografts / metabolism*
  • Humans
  • Mice
  • Nuclear Receptor Co-Repressor 1 / metabolism*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism*
  • Protein Kinase Inhibitors / pharmacology
  • src-Family Kinases / metabolism*

Substances

  • NCOR1 protein, human
  • Nuclear Receptor Co-Repressor 1
  • Protein Kinase Inhibitors
  • lyn protein-tyrosine kinase
  • src-Family Kinases
  • Dasatinib