Abstract
We have isolated and sequenced two cDNA clones coding for plasminogen activator inhibitor 2 (PAI-2). The cDNA was used to study the regulation of PAI-2 gene transcription by the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate in the human histiocytic lymphoma cell line U-937. The tumor promoter caused a transient, 50-fold increase of PAI-2 gene transcription.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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Cell Differentiation / drug effects
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DNA / genetics
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DNA, Recombinant
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Escherichia coli / genetics
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Glycoproteins / genetics*
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Humans
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Lymphoma, Large B-Cell, Diffuse / metabolism
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Lymphoma, Large B-Cell, Diffuse / pathology*
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Molecular Sequence Data
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Plasmids
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Plasminogen Inactivators
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RNA, Messenger / biosynthesis
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Templates, Genetic
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Tetradecanoylphorbol Acetate / pharmacology*
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Transcription, Genetic / drug effects*
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Transformation, Genetic
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Tumor Cells, Cultured
Substances
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DNA, Recombinant
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Glycoproteins
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Plasminogen Inactivators
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RNA, Messenger
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DNA
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Tetradecanoylphorbol Acetate