MTA2 triggered R-loop trans-regulates BDH1-mediated β-hydroxybutyrylation and potentiates propagation of hepatocellular carcinoma stem cells

Signal Transduct Target Ther. 2021 Apr 2;6(1):135. doi: 10.1038/s41392-021-00464-z.

Heng Zhang^{1

2}, Zhi Chang^{1

2}, Lu-Ning Qin¹, Bin Liang², Jing-Xia Han², Kai-Liang Qiao¹, Cheng Yang^{1

2}, Yan-Rong Liu^{3

4}, Hong-Gang Zhou⁵, Tao Sun^{6

7

8}

¹ State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China.
² Tianjin Key Laboratory of Early Druggability Evaluation of Innovative Drugs and Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, China.
³ Tianjin Key Laboratory of Early Druggability Evaluation of Innovative Drugs and Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, China. liuyanrong1984@163.com.
⁴ Molecular Pathology Institute of Gastrointestinal Tumors, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China. liuyanrong1984@163.com.
⁵ State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China. honggang.zhou@nankai.edu.cn.
⁶ State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China. tao.sun@nankai.edu.cn.
⁷ Molecular Pathology Institute of Gastrointestinal Tumors, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China. tao.sun@nankai.edu.cn.
⁸ Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin Institute of Digestive Disease, Tianjin, China. tao.sun@nankai.edu.cn.

No abstract available

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