Chronic Brain Failure

Emerg Med Clin North Am. 2021 May;39(2):307-322. doi: 10.1016/j.emc.2021.01.008.

Abstract

Chronic brain failure, also known as dementia or major neurocognitive disorder, is a syndrome of progressive functional decline characterized by both cognitive and neuropsychiatric symptoms. It can be conceptualized like other organ failure syndromes and its impact on quality of life can be mitigated with proper treatment. Dementia is a risk factor for delirium, and their symptoms can be similar. Patients with dementia can present with agitation that can lead to injury. Logic and reason are rarely successful when attempting to redirect someone with advanced dementia. Interactions that offer a sense of choice are more likely to succeed.

Keywords: Agitation; Dementia; Emergency; Neurocognitive; Neuropsychiatric.

Publication types

  • Review

MeSH terms

  • Aged
  • Antidepressive Agents / therapeutic use
  • Antipsychotic Agents / therapeutic use
  • Benzodiazepines / therapeutic use
  • Cholinesterase Inhibitors / therapeutic use
  • Delirium / diagnosis
  • Dementia / diagnosis*
  • Dementia / drug therapy
  • Dementia / etiology
  • Diagnosis, Differential
  • Emergency Medicine
  • Humans
  • Incidence
  • Memantine / therapeutic use
  • Mental Competency
  • Neurocognitive Disorders / diagnosis*
  • Neurocognitive Disorders / drug therapy
  • Neurocognitive Disorders / etiology
  • Neuropsychological Tests
  • Pain / diagnosis
  • Prevalence
  • Psychomotor Agitation / prevention & control

Substances

  • Antidepressive Agents
  • Antipsychotic Agents
  • Cholinesterase Inhibitors
  • Benzodiazepines
  • Memantine