TTP-mediated regulation of mRNA stability in immune cells contributes to adaptive immunity, immune tolerance and clinical applications

RNA Biol. 2021 Dec;18(12):2150-2156. doi: 10.1080/15476286.2021.1917185. Epub 2021 Apr 27.

Abstract

Dendritic cells (DCs) form a sentinel network to induce protective immunity against pathogens or self-tolerance. mRNA stability is an important part of the post-transcriptional regulation (PTR) that controls the maturation and function of DCs. In this review, we summarize the effects of TTP-mediated regulation of mRNA stability in DCs, focusing on DC maturation and antigen presentation, T cell activation and differentiation, immune tolerance and inflammation. We also discuss the potential DC-based immune treatment for HIV+ patients through regulation of mRNA stability. This review proposes the regulation of mRNA stability as a novel immune therapy for various inflammatory diseases, such as arthritis and dermatitis.

Keywords: Dendritic cells; TTP; Zfp36; adaptive immunity; clinical application; immune tolerance; mRNA stability.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity
  • Antigen Presentation
  • Dendritic Cells / metabolism*
  • HIV Infections / genetics
  • HIV Infections / immunology*
  • Humans
  • Immune Tolerance
  • RNA Stability
  • RNA, Messenger / chemistry*
  • Tristetraprolin / metabolism*

Substances

  • RNA, Messenger
  • Tristetraprolin
  • ZFP36 protein, human

Grants and funding

This work was supported by grants from the National Natural Science Foundation of China (Nos. 31670889 and 31200668) and the National Key Research and Development Project of China (Nos. 2016YFA0502204).