Aurora A kinase activation: Different means to different ends

J Cell Biol. 2021 Sep 6;220(9):e202106128. doi: 10.1083/jcb.202106128. Epub 2021 Jul 21.

Abstract

Aurora A is a serine/threonine kinase essential for mitotic entry and spindle assembly. Recent molecular studies have revealed the existence of multiple, distinct mechanisms of Aurora A activation, each occurring at specific subcellular locations, optimized for cellular context, and primed by signaling events including phosphorylation and oxidation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allosteric Regulation
  • Animals
  • Aurora Kinase A / genetics*
  • Aurora Kinase A / metabolism
  • Cell Cycle Proteins / genetics*
  • Cell Cycle Proteins / metabolism
  • Eukaryotic Cells / cytology
  • Eukaryotic Cells / enzymology
  • Humans
  • Microtubule-Associated Proteins / genetics*
  • Microtubule-Associated Proteins / metabolism
  • Microtubules / metabolism
  • Microtubules / ultrastructure
  • Mitosis*
  • Oxidation-Reduction
  • Phosphorylation
  • Protein Binding
  • Protein Processing, Post-Translational*
  • Signal Transduction
  • Spindle Apparatus / metabolism
  • Spindle Apparatus / ultrastructure

Substances

  • Cell Cycle Proteins
  • Microtubule-Associated Proteins
  • TPX2 protein, human
  • bora protein, human
  • AURKA protein, human
  • Aurora Kinase A

Grants and funding