Mutations in CRBN and other cereblon pathway genes are infrequently associated with acquired resistance to immunomodulatory drugs

Leukemia. 2021 Oct;35(10):3017-3020. doi: 10.1038/s41375-021-01373-4. Epub 2021 Aug 9.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics*
  • Biomarkers, Tumor / genetics*
  • Drug Resistance, Neoplasm*
  • Humans
  • Immunomodulating Agents / therapeutic use*
  • Multiple Myeloma / drug therapy
  • Multiple Myeloma / genetics
  • Multiple Myeloma / pathology*
  • Mutation*
  • Ubiquitin-Protein Ligases / genetics*

Substances

  • Adaptor Proteins, Signal Transducing
  • Biomarkers, Tumor
  • CRBN protein, human
  • Immunomodulating Agents
  • Ubiquitin-Protein Ligases