The number 13 of the family: a proliferation inducing ligand

Curr Opin Immunol. 2021 Aug:71:132-137. doi: 10.1016/j.coi.2021.06.018. Epub 2021 Aug 16.

Abstract

The TNF superfamily member a proliferation inducing ligand (APRIL, TNFSF13) plays a late role in humoral immunity at the level of antibody-producing plasmocytes. The recent characterization of the first immunodeficient patient with an inactivating mutation in the APRIL gene provided the last piece of functional data lacking in the human system. Based on this function, APRIL has been considered as a valuable target to dampen unwanted antibody production. After reviewing the late data acquired on the physiological function of APRIL in humoral immunity, we will here review the state of the art regarding APRIL targeting in autoimmune diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autoimmune Diseases / immunology*
  • Cell Proliferation
  • Humans
  • Ligands
  • Tumor Necrosis Factor Ligand Superfamily Member 13 / genetics
  • Tumor Necrosis Factor Ligand Superfamily Member 13 / immunology*

Substances

  • Ligands
  • TNFSF13 protein, human
  • Tumor Necrosis Factor Ligand Superfamily Member 13