Background/aim: Adjuvant platinum-based chemotherapy (APC) has been the standard of care for patients with non-small-cell lung cancer (NSCLC) who have undergone complete pulmonary resection. This study analyzed the clinical and prognostic significance of immunonutritional indices in NSCLC patients receiving APC.
Patients and methods: We retrospectively reviewed 110 patients from 2008 to 2016. Three immunonutritional indices were calculated: neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and prognostic nutritional index (PNI).
Results: The median age was 64 years, and 66 patients were males. Each index showed a significant correlation with primary tumor length. NLR and PLR were significantly correlated with vascular invasion. Prognostic analyses revealed that each index was significantly correlated with postoperative recurrence-free survival (RFS) and overall survival (OS). On multivariate analyses, PNI was an independent predictor of RFS and OS.
Conclusion: Host immunonutritional status may have a significant effect on the postoperative prognosis of NSCLC in patients receiving APC.
Keywords: Non-small-cell lung cancer; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; prognostic factor; prognostic nutritional index.
Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.