KPNA1 regulates nuclear import of NCOR2 splice variant BQ323636.1 to confer tamoxifen resistance in breast cancer

Clin Transl Med. 2021 Oct;11(10):e554. doi: 10.1002/ctm2.554.

Authors

Affiliations

¹ Department of Pathology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
² Department of Clinical Oncology, Queen Mary Hospital, Hong Kong, China.
³ Department of Clinical Oncology, LKS Faculty of Medicine, The University of Hong Kong, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Active Transport, Cell Nucleus / genetics
Breast Neoplasms / drug therapy*
Breast Neoplasms / genetics*
Breast Neoplasms / metabolism
Drug Resistance
Female
Humans
Nuclear Receptor Co-Repressor 2 / genetics*
Nuclear Receptor Co-Repressor 2 / metabolism
Tamoxifen / pharmacology*
alpha Karyopherins / genetics*
alpha Karyopherins / metabolism

Substances

KPNA1 protein, human
NCOR2 protein, human
Nuclear Receptor Co-Repressor 2
alpha Karyopherins
Tamoxifen