Associated factors and distribution of posterior corneal astigmatism in a middle-aged population

Clinical relevance: Posterior corneal astigmatism has an important role in diagnosis and treatment of astigmatism, but it is usually overlooked.

Background: This cross-sectional study aimed to investigate the distribution of posterior corneal astigmatism (PCA) and its associated factors in a middle-aged population that participated in the Shahroud Eye Cohort Study (ShECS) phase II.

Methods: Anterior corneal astigmatism (ACA) and PCA values were measured using rotating Scheimpflug System (Pentacam HR, Oculus). With-the-rule (WTR) astigmatism was considered when the steepest corneal meridian was aligned within 90° ± 30°, and against-the-rule (ATR) astigmatism when the steepest meridian was 0 ± 30°. All the remaining values were considered as oblique astigmatism. Logistic regression models were used for evaluating the association of PCA magnitudes with other factors.

Results: The current study consisted of 3871 eyes with available Pentacam data. Mean age of participants was 55.4 ± 6.1 years and 1557 (40.2%) subjects were male. Means of ACA and PCA were 0.77 ± 0.67 and -0.24 ± 0.15 D, respectively. The majority of PCA consisted of WTR astigmatism (82.43%), while ACA mostly showed ATR astigmatism (55.46%). PCA > 0.3 D was associated with male sex (OR = 1.16, P-value = 0.028) and spherical equivalent (OR = 0.93, P-value = 0.011) in the adjusted model, while PCA > 0.5 dioptre was strongly associated with myopia (OR = 4.6, P-value < 0.001).

Conclusion: The most common forms of ACA and PCA in middle-aged Iranian adults were ATR and WTR, respectively. While the shape of posterior corneal surface remained mostly unchanged across ages of 45 to 69 years, ACA was associated with a decrease in ATR proportion. Moreover, the most significant factors associated with higher magnitudes of PCA were male sex and myopia.