Pituitary stalk interruption syndrome (PSIS) is a rare disease with isolated growth hormone deficiency or multiple anterior pituitary hormone deficiencies; and is characterised by a thin or absent pituitary stalk, hypoplasia of the adenohypophysis, and ectopic neurohypophysis. The literature have reported primarily on cases of infants and young people, and there are few reports in adults. A case is presented here of a 54-year male, who reported dizziness accompanied by fatigue and anorexia for more than 20 days; and the results from the blood tests showed a general decline in growth hormone, thyrotropin, and sex hormone levels. On the basis of the medical history, laboratory and imaging examination, a diagnosis of PSIS was made. After treatment, the patient's condition as well as laboratory results returned to normal. In summary, PSIS can also occur in adults. In the suspected cases, magnetic resonance imaging should be done in time to diagnose and manage it appropriately early in the course of the disease. Key Words: Pituitary stalk interruption syndrome, Pituitary hormone deficiency, Adults.