Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis

Shuai Zhang; Ornella D Nelson; Ian R Price; Chengliang Zhu; Xuan Lu; Irma R Fernandez; Robert S Weiss; Hening Lin

doi:10.1073/pnas.2117013119

Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis

Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2117013119. doi: 10.1073/pnas.2117013119. Epub 2022 Mar 8.

Authors

Shuai Zhang^{1

2}, Ornella D Nelson², Ian R Price², Chengliang Zhu², Xuan Lu², Irma R Fernandez^{2

3}, Robert S Weiss³, Hening Lin^{1

2}

Affiliations

¹ Howard Hughes Medical Institute, Cornell University, Ithaca, NY 14853.
² Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
³ Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853.

Abstract

SignificanceThe study provided a long-sought molecular mechanism that could explain the link between fatty acid metabolism and cancer metastasis. Further understanding may lead to new strategies to inhibit cancer metastasis. The chemical proteomic approach developed here will be useful for discovering other regulatory mechanisms of protein function by small molecule metabolites.

Keywords: NME1; NME2; fatty acid; long-chain fatty acyl coenzyme A; tumor metastasis.

MeSH terms

Acyl Coenzyme A / metabolism*
Breast Neoplasms
Endocytosis
Female
Humans
NM23 Nucleoside Diphosphate Kinases / antagonists & inhibitors*
Neoplasm Metastasis
Neoplasms / etiology
Neoplasms / metabolism*
Neoplasms / pathology*
Protein Binding
Proteome
Proteomics / methods

Substances

Acyl Coenzyme A
NM23 Nucleoside Diphosphate Kinases
Proteome
NME1 protein, human
NME2 protein, human

Abstract

MeSH terms

Substances

Grants and funding