Management and Cure of Gouty Arthritis

Rheum Dis Clin North Am. 2022 May;48(2):479-492. doi: 10.1016/j.rdc.2022.03.001.

Abstract

Gout is the most common inflammatory arthritis in the United States. Gouty arthritis is associated with significant morbidity and mortality and is the result of chronic hyperuricemia. Gout is effectively managed and potentially cured by decreasing the overall urate burden with serum urate-lowering therapy. When serum urate is maintained at less than 6.0 mg/dL, urate deposition is resolved, and gout can be cured. Unfortunately, because of less than optimal physician monitoring and dose escalation, many patients do not achieve these urate levels.

Keywords: Gout; Hyperuricemia; Inflammatory arthritis; Treat-to-target; Uric acid.

Publication types

  • Review

MeSH terms

  • Arthritis, Gouty* / complications
  • Arthritis, Gouty* / drug therapy
  • Gout Suppressants / therapeutic use
  • Gout*
  • Humans
  • Hyperuricemia* / drug therapy
  • Hyperuricemia* / etiology
  • Uric Acid

Substances

  • Gout Suppressants
  • Uric Acid