IgG4-positive Hashimoto thyroiditis and its association with IgG4-related sclerosing disease

BMJ Case Rep. 2022 Jul 6;15(7):e249181. doi: 10.1136/bcr-2022-249181.

Abstract

A woman in her 50s was referred with suspected thyroid malignancy and underwent total thyroidectomy. Immunohistochemical analysis revealed IgG4-positive Hashimoto's thyroiditis. IgG4-related thyroid disease is poorly understood, and thought to encompass various entities including IgG4-positive Hashimoto's thyroiditis, Fibrosing Variant of Hashimoto's thyroiditis, Reidel's thyroiditis and Graves' disease with elevated IgG4 levels. Furthermore, it may be associated with a systemic fibrosing condition called 'IgG4-related sclerosing disease'. The clinical significance of IgG4-positive thyroid disease, however, remains unclear.

Keywords: Ear, nose and throat/otolaryngology; Thyroiditis.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Graves Disease* / complications
  • Graves Disease* / diagnosis
  • Graves Disease* / surgery
  • Hashimoto Disease* / complications
  • Hashimoto Disease* / diagnosis
  • Humans
  • Immunoglobulin G
  • Immunoglobulin G4-Related Disease* / complications
  • Immunoglobulin G4-Related Disease* / diagnosis
  • Immunologic Tests

Substances

  • Immunoglobulin G