Latent Autoimmune Diabetes in Adults and Metabolic Syndrome-A Mini Review

Niansi Pan; Shimei Yang; Xiaohong Niu

doi:10.3389/fendo.2022.913373

Latent Autoimmune Diabetes in Adults and Metabolic Syndrome-A Mini Review

Front Endocrinol (Lausanne). 2022 Jun 28:13:913373. doi: 10.3389/fendo.2022.913373. eCollection 2022.

Authors

Niansi Pan¹, Shimei Yang¹, Xiaohong Niu²

Affiliations

¹ Department of Endocrinology, Changzhi Medical College, Changzhi, China.
² Department of Endocrinology, Changzhi Medical College Affiliated Heji Hospital, Changzhi, China.

Abstract

Latent autoimmune diabetes in adults (LADA) is a heterogeneous subtype of diabetes characterized by islet cell destruction mediated by islet autoimmunity and insulin resistance. Metabolic syndrome (MetS) is a state in which many risk factors for metabolic and cardiovascular diseases accumulate in an individual. Based on clinical data, this review covers the prevalence of MetS in LADA, focusing on the risk associated with and the role of insulin resistance in the development of LADA from the perspective of inflammatory factors, environmental factors, and the gut microbiota, aiming to improve our understanding of this condition.

Keywords: Insulin Resistance; LADA; Latent Autoimmune Diabetes in Adults; MetS; Metabolic Syndrome; Obesity; type 1 diabetes mellitus; type 2 diabetes mellitus.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Autoantibodies
Diabetes Mellitus, Type 1*
Glucose Intolerance*
Humans
Insulin Resistance*
Latent Autoimmune Diabetes in Adults*
Metabolic Syndrome* / epidemiology

Substances

Autoantibodies