Cancer therapy duration is variable and may take years, adding a new challenge of maintaining the best life quality for cancer survivors. In cancer patients, late-onset toxicities have been reported with monoclonal antibodies and may involve several body organs or systems. They are defined as an autoimmune illnesses that can happen months to years after treatment discontinuation. Late-onset toxicities have become a focus of clinical care and related research. After cancer therapy is completed, the patient should receive longitudinal follow-up to detect these late effects as early as possible. The current review summarizes the recently reported late-onset toxicities of four classes of monoclonal antibodies (anti-CD52, anti-CTLA-4, anti-PD-1 and anti-CD20) with guidance for the diagnostic tools, appropriate management and treatment.
Keywords: anti-CD20; anti-CD52; anti-CTLA-4; delayed immune-related event; immune checkpoints inhibitors; late-onset toxicity; monoclonal antibodies.
Late-onset toxicities have been reported in cancer patients with monoclonal antibodies therapy and may involve several body organs or systems. They are defined as autoimmune illnesses that can happen months to years after treatment discontinuation. The reported late-onset toxicities include; bruises due to decreased platelet count associated with alemtuzumab, ipilimumab-induced pneumonitis, hepatitis, gastrointestinal disorders, cardiovascular complications and neurosarcoidosis. Moreover, endocrinal side effects of nivolumab, pembrolizumab-induced colitis, dermatological toxicities and acute encephalopathy, and rituximab-induced late-onset decrease in neutrophils count. Several treatment options are available for managing late-onset toxicities, including corticosteroids. After monoclonal antibodies therapy is completed in cancer patients, they should receive a longitudinal follow-up to detect these late effects as early as possible.