Acute respiratory distress syndrome in adults: diagnosis, outcomes, long-term sequelae, and management

Ellen A Gorman; Cecilia M O'Kane; Daniel F McAuley

doi:10.1016/S0140-6736(22)01439-8

Acute respiratory distress syndrome in adults: diagnosis, outcomes, long-term sequelae, and management

Lancet. 2022 Oct 1;400(10358):1157-1170. doi: 10.1016/S0140-6736(22)01439-8. Epub 2022 Sep 4.

Authors

Ellen A Gorman¹, Cecilia M O'Kane¹, Daniel F McAuley²

Affiliations

¹ Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.
² Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK. Electronic address: d.f.mcauley@qub.ac.uk.

PMID: 36070788
DOI: 10.1016/S0140-6736(22)01439-8

Abstract

Acute respiratory distress syndrome (ARDS) is characterised by acute hypoxaemic respiratory failure with bilateral infiltrates on chest imaging, which is not fully explained by cardiac failure or fluid overload. ARDS is defined by the Berlin criteria. In this Series paper the diagnosis, management, outcomes, and long-term sequelae of ARDS are reviewed. Potential limitations of the ARDS definition and evidence that could inform future revisions are considered. Guideline recommendations, evidence, and uncertainties in relation to ARDS management are discussed. The future of ARDS strives towards a precision medicine approach, and the framework of treatable traits in ARDS diagnosis and management is explored.

Publication types

Review

MeSH terms

Adult
Diagnostic Imaging
Humans
Phenotype
Respiratory Distress Syndrome* / diagnosis
Respiratory Distress Syndrome* / etiology
Respiratory Distress Syndrome* / therapy
Respiratory Insufficiency*