The present study reports on variables associated with psychopathology in children of patients hospitalized with major affective disorders. The primary instrument used in this investigation was a structured diagnostic interview that was completed by a child psychiatrist. Univariate and multivariate statistical analyses of these data suggest that severity of parental psychopathology (as measured by a higher score on the SCL-90 and a longer stay in the hospital) and the report of child abuse were associated with general childhood psychopathology. The significance of these and other findings are discussed.