Trapping Tribbles: Nanobody-assisted structure of the TRIB2 pseudokinase

Frederick R Santana; Edmond M Linossi; Natalia Jura

doi:10.1016/j.str.2022.10.006

Trapping Tribbles: Nanobody-assisted structure of the TRIB2 pseudokinase

Structure. 2022 Nov 3;30(11):1465-1467. doi: 10.1016/j.str.2022.10.006.

Authors

Frederick R Santana¹, Edmond M Linossi¹, Natalia Jura²

Affiliations

¹ Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158, USA.
² Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94158, USA. Electronic address: natalia.jura@ucsf.edu.

PMID: 36332608
DOI: 10.1016/j.str.2022.10.006

Abstract

TRIB2, a member of the human Tribbles pseudokinase family, functions as a molecular scaffold in diverse signaling pathways. In this issue of Structure, Jamieson et al. report the first high-resolution structure of TRIB2 bound to a nanobody that offers insights into its "active-like" state.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Comment

MeSH terms

Calcium-Calmodulin-Dependent Protein Kinases* / metabolism
Humans
Intracellular Signaling Peptides and Proteins* / genetics
Intracellular Signaling Peptides and Proteins* / metabolism
Protein Serine-Threonine Kinases / genetics
Signal Transduction

Substances

Calcium-Calmodulin-Dependent Protein Kinases
Intracellular Signaling Peptides and Proteins
Protein Serine-Threonine Kinases
TRIB2 protein, human

Grants and funding

R35 GM139636/GM/NIGMS NIH HHS/United States