Abstract
A portion of the Duchenne muscular dystrophy (DMD) gene transcript from human fetal skeletal muscle and mouse adult heart was sequenced, representing approximately 25 percent of the total, 14-kb DMD transcript. The nucleic acid and predicted amino acid sequences from the two species are nearly 90 percent homologous. The amino acid sequence that is predicted from this portion of the DMD gene indicates that the protein product might serve a structural role in muscle, but the abundance and tissue distribution of the messenger RNA suggests that the DMD protein is not nebulin.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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DNA / genetics*
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DNA, Recombinant
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Exons
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Humans
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Male
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Mice
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Molecular Sequence Data
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Muscle Proteins / genetics
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Muscles / analysis
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Muscles / embryology
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Muscular Dystrophies / genetics*
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Muscular Dystrophy, Animal / genetics*
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Myocardium / analysis
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Nucleic Acid Hybridization
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RNA, Messenger / genetics
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X Chromosome
Substances
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DNA, Recombinant
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Muscle Proteins
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RNA, Messenger
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nebulin
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DNA
Associated data
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GENBANK/M17154
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GENBANK/M18025
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GENBANK/M18026
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GENBANK/M18533