Eosinophilic granulomatosis with polyangiitis

Med Clin (Barc). 2023 Apr 6;160(7):310-317. doi: 10.1016/j.medcli.2023.01.003. Epub 2023 Feb 9.
[Article in English, Spanish]

Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic vasculitis characterized by the presence of asthma associated with eosinophilia, eosinophilic infiltration of different organs, and vasculitis of small and medium-sized vessels. Although classified as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, it occurs in less than half of the patients. The disease is infrequent, typically appearing in patients with asthma and affecting multiple organs such as lung, skin and peripheral nervous system. Treatment has been based on the use of glucocorticoids and immunosuppressants. In recent years, progress has been made in the knowledge of the pathophysiology, in treatment with the inclusion of biologic agents, the classification criteria have been revised and new therapeutic recommendations have been published.

Keywords: Eosinofilia; Eosinophilia; Eosinophilic granulomatosis with polyangiitis; Granulomatosis eosinofílica con poliangeítis; Systemic vasculitis; Vasculitis sistémica.

Publication types

  • Review

MeSH terms

  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis* / complications
  • Antibodies, Antineutrophil Cytoplasmic
  • Asthma* / complications
  • Churg-Strauss Syndrome* / complications
  • Churg-Strauss Syndrome* / diagnosis
  • Churg-Strauss Syndrome* / drug therapy
  • Eosinophilia* / complications
  • Eosinophilia* / etiology
  • Granulomatosis with Polyangiitis* / complications
  • Granulomatosis with Polyangiitis* / diagnosis
  • Granulomatosis with Polyangiitis* / drug therapy
  • Humans

Substances

  • Antibodies, Antineutrophil Cytoplasmic