Primary Cutaneous Mucormycosis: A Necrotising Soft Tissue Infection with Poor Prognosis

Infect Disord Drug Targets. 2023;23(6):e040523216523. doi: 10.2174/1871526523666230504114801.

Abstract

Background: Cutaneous mucormycosis is an unusual fungal infection that continues to occur. It needs aggressive surgical debridement and timely administration of antifungals due to its high fatality rate. High clinical suspicion on the part of a surgeon is required to prevent the same.

Case presentation: We present two cases of cutaneous mucormycosis in which the patients succumbed to death, highlighting the seriousness of the condition. One patient had a lower leg ulcer and was diabetic, and the other patient had a gluteal abscess following an intramuscular injection. Tissue samples grew Rhizopus arrhizus and Apophysomyces sp., respectively. Both patients were treated with amphotericin B, and extensive debridement was performed.

Discussion: Cutaneous mucormycosis can be reported in immunocompetent people, and there is a need for early recognition of the entity as a differential diagnosis of any nonhealing necrotic ulcer.

Conclusion: Proper training and education of technical and clinical staff should be done at peripheral primary and secondary care centres so as not to miss out on cases of mucormycosis and for better prognosis in a cutaneous variety of mucormycosis in surgical patients.

Keywords: Cutaneous; Rhizopus; apophysomyces; mucormycosis; necrotizing; prognosis; surgical patients.

Publication types

  • Case Reports

MeSH terms

  • Amphotericin B / therapeutic use
  • Antifungal Agents / therapeutic use
  • Humans
  • Mucormycosis* / complications
  • Mucormycosis* / diagnosis
  • Mucormycosis* / drug therapy
  • Skin
  • Soft Tissue Infections* / diagnosis
  • Soft Tissue Infections* / drug therapy

Substances

  • Amphotericin B
  • Antifungal Agents