The role of RNA splicing factor PTBP1 in neuronal development

Biochim Biophys Acta Mol Cell Res. 2023 Oct;1870(7):119506. doi: 10.1016/j.bbamcr.2023.119506. Epub 2023 May 31.

Abstract

Alternative pre-mRNA splicing, which produces various mRNA isoforms with distinct structures and functions from a single gene, is regulated by specific RNA-binding proteins and is an essential method for regulating gene expression in mammals. Recent studies have shown that abnormal change during neuronal development triggered by splicing mis-regulation is an important feature of various neurological diseases. Polypyrimidine tract binding protein 1 (PTBP1) is a kind of RNA-binding proteins with extensive biological functions. As a well-known splicing regulator, it affects the neuronal development process through its involvement in axon formation, synaptogenesis, and neuronal apoptosis, according to the most recent studies. Here, we summarized the mechanism of alternative splicing, structure and function of PTBP1, and the latest research progress on the role of alternative splicing events regulated by PTBP1 in axon formation, synaptogenesis and neuronal apoptosis, to reveal the mechanism of PTBP1-regulated changes in neuronal development process.

Keywords: Alternative splicing; Axon formation; Neuronal apoptosis; Polypyrimidine tract binding protein 1; Synaptogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Mammals / genetics
  • Mammals / metabolism
  • Nervous System Diseases* / genetics
  • Neurogenesis* / genetics
  • Polypyrimidine Tract-Binding Protein* / genetics
  • Polypyrimidine Tract-Binding Protein* / metabolism
  • RNA Splicing
  • RNA Splicing Factors / genetics
  • RNA Splicing Factors / metabolism
  • RNA* / metabolism
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism

Substances

  • Polypyrimidine Tract-Binding Protein
  • RNA
  • RNA Splicing Factors
  • RNA-Binding Proteins