Personalized Care in Long QT Syndrome: Better Management, More Sports, and Fewer Devices

Ciorsti J MacIntyre; Michael J Ackerman

doi:10.1016/j.ccep.2023.04.007

Personalized Care in Long QT Syndrome: Better Management, More Sports, and Fewer Devices

Card Electrophysiol Clin. 2023 Sep;15(3):285-291. doi: 10.1016/j.ccep.2023.04.007. Epub 2023 Jun 9.

Authors

Ciorsti J MacIntyre¹, Michael J Ackerman²

Affiliations

¹ Department of Cardiovascular Medicine, Division of Heart Rhythm Services, Windland Smith Rice Genetic Heart Rhythm Clinic, Mayo Clinic, Rochester, MN, USA. Electronic address: macintyre.ciorsti@mayo.edu.
² Department of Cardiovascular Medicine, Division of Heart Rhythm Services, Windland Smith Rice Genetic Heart Rhythm Clinic, Mayo Clinic, Rochester, MN, USA; Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology, Mayo Clinic, Rochester, MN, USA; Department of Molecular Pharmacology & Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN, USA.

PMID: 37558299
DOI: 10.1016/j.ccep.2023.04.007

Abstract

Long QT Syndrome (LQTS) is a potentially life-threatening yet highly treatable inherited cardiac channelopathy. When evaluating these patients, it is important to consider patient-specific as well as genotype-specific factors in order to adequately encompass the many nuances to care that exist in its management. The tendency to follow a "one-size-fits-all" approach needs to be replaced by treatment strategies that embrace the unique considerations of the individual patient in the context of their genotype. Herein, the authors aim to review the spectrum of LQTS, including the considerations when tailoring a personalized, genotype-tailored treatment program for a patient's LQTS.

Keywords: Genetics; Long QT syndrome; QT interval.

Publication types

Review

MeSH terms

Arrhythmias, Cardiac / genetics
Electrocardiography
Genotype
Humans
Long QT Syndrome* / genetics
Long QT Syndrome* / therapy
Sports*