Progress of epigenetic modification of SATB2 gene in the pathogenesis of non-syndromic cleft lip and palate

Asian J Surg. 2024 Jan;47(1):72-76. doi: 10.1016/j.asjsur.2023.09.113. Epub 2023 Oct 16.

Abstract

Non-syndromic Cleft Lip and Palate (NSCLP) is one of the most common congenital craniofacial malformations. However, there is no enough knowledge about its mechanism, even through many relevant studies verify that cleft lip and palate is caused by interactions between environmental and genetic factors. SATB2 gene is one of the most common candidate genes of NSCLP, and the development of epigenetics provides a new direction on pathogenesis of cleft lip and palate. This review summarizes SATB2 gene in the pathogenesis of non-syndromic cleft lip and palate, expecting to provide strategies to prevent and treat cleft and palate in the future.

Keywords: Epigenetics; Non-syndromic cleft lip and palate; SATB2 gene.

Publication types

  • Review

MeSH terms

  • Cleft Lip* / genetics
  • Cleft Palate* / genetics
  • Epigenesis, Genetic / genetics
  • Humans
  • Matrix Attachment Region Binding Proteins* / genetics
  • Polymorphism, Single Nucleotide
  • Transcription Factors / genetics

Substances

  • SATB2 protein, human
  • Transcription Factors
  • Matrix Attachment Region Binding Proteins