GPx1 promotes hypertrophic differentiation of chondrocytes through modulation of akt signaling in a non-monotonic manner

Sijia Mi; Jinhong Zhang; Mengyao Sun; Xinyu Huo; Yaqi Lv; Frank Beier; Shemin Lu; Jidong Yan

doi:10.1016/j.yexcr.2023.113824

GPx1 promotes hypertrophic differentiation of chondrocytes through modulation of akt signaling in a non-monotonic manner

Exp Cell Res. 2023 Dec 15;433(2):113824. doi: 10.1016/j.yexcr.2023.113824. Epub 2023 Oct 27.

Authors

Sijia Mi¹, Jinhong Zhang², Mengyao Sun³, Xinyu Huo⁴, Yaqi Lv⁵, Frank Beier⁶, Shemin Lu⁷, Jidong Yan⁸

Affiliations

¹ Department of Human Anatomy, Histology, And Embryology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, PR China; Institute of Molecular and Translational Medicine, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, PR China. Electronic address: misijiacn@163.com.
² Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, PR China. Electronic address: zihxj135@stu.xjtu.cn.
³ Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, PR China. Electronic address: mengyaosun@xjtu.edu.cn.
⁴ Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, PR China. Electronic address: hyx980606@163.com.
⁵ Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, PR China. Electronic address: lvyaqi@stu.xjtu.edu.cn.
⁶ Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. Electronic address: fbeier@uwo.ca.
⁷ Institute of Molecular and Translational Medicine, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, PR China; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, PR China. Electronic address: lushemin@mail.xjtu.edu.cn.
⁸ Department of Human Anatomy, Histology, And Embryology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, PR China; Institute of Molecular and Translational Medicine, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, PR China; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, Shaanxi, 710061, PR China. Electronic address: yanjidong@xjtu.edu.cn.

PMID: 37890608
DOI: 10.1016/j.yexcr.2023.113824

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Differentiation
Chondrocytes* / metabolism
Glutathione Peroxidase GPX1 / metabolism
Hypertrophy
Mice
Proto-Oncogene Proteins c-akt* / genetics
Proto-Oncogene Proteins c-akt* / metabolism
Signal Transduction

Substances

Proto-Oncogene Proteins c-akt
Glutathione Peroxidase GPX1