The role of carcinoembryonic antigen-related cell adhesion molecule 1 in cancer

Lisa Götz; Uwe Rueckschloss; Gözde Balk; Verena Pfeiffer; Süleyman Ergün; Florian Kleefeldt

doi:10.3389/fimmu.2023.1295232

The role of carcinoembryonic antigen-related cell adhesion molecule 1 in cancer

Front Immunol. 2023 Nov 24:14:1295232. doi: 10.3389/fimmu.2023.1295232. eCollection 2023.

Authors

Lisa Götz¹, Uwe Rueckschloss¹, Gözde Balk¹, Verena Pfeiffer¹, Süleyman Ergün¹, Florian Kleefeldt^{1

2}

Affiliations

¹ Institute of Anatomy and Cell Biology, Julius-Maximilians-University Würzburg, Würzburg, Germany.
² Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, United States.

Abstract

The Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), also known as CD66a, is a member of the immunoglobulin superfamily. CEACAM1 was shown to be a prognostic marker in patients suffering from cancer. In this review, we summarize pre-clinical and clinical evidence linking CEACAM1 to tumorigenicity and cancer progression. Furthermore, we discuss potential CEACAM1-based mechanisms that may affect cancer biology.

Keywords: CEA; CEACAM1; cancer; malignancy; metastasis; signaling; tumor.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Antigens, CD / metabolism
CEACAM1 Protein
Carcinoembryonic Antigen / metabolism
Cell Adhesion Molecules* / metabolism
Humans
Neoplasms*

Substances

Antigens, CD
Carcinoembryonic Antigen
CEACAM1 Protein
Cell Adhesion Molecules
CD66 antigens

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Walter Schulz Foundation (Planegg, Germany) and the Cancer Research Advancement Foundation (Forschung hilft) at the University of Würzburg (Würzburg, Germany).