Association between interleukin-12 +1188A/C polymorphism and the risk of tuberculosis: A meta-analysis

Background: The role of interleukin-12(IL-12) gene +1188A/C polymorphism has been indicated in the progression of tuberculosis (TB). Nevertheless, the outcomes remain controversial.

Objectives: This meta-analysis focused on examining the association between IL-12 +1188A/C polymorphism and TB.

Methods: EMBASE and PubMed databases were searched to identify relevant studies for retrospective analysis. Then, a random- or fixed-effects model was utilized to calculate the combined odds ratios (ORs) as well as corresponding 95% confidence intervals (CIs).

Results: A total of 9 related articles were discovered. The result of meta-analysis showed that IL-12 +1188A/C polymorphism did not show significant correlation with TB risk among the total population (C vs A: OR =0.66, 95% CI=0.41-1.05; AC vs AA: OR = 1.28, 95% CI =0.90-1.82; CC vs AA: OR =0.95, 95% CI=0.80-1.14; recessive model: OR =1.00, 95% CI = 0.75-1.34; dominant model: OR =1.07, 95% CI =0.94-1.21). As discovered from subgroup analyses based on race and HWE, this polymorphism did not show relationship with TB risk.

Conclusion: The present findings indicated that IL-12 +1188A/C polymorphism was not related to the risk of TB.