The role of the c-mos gene in the 8;21 translocation in human acute myeloblastic leukemia

Science. 1985 Aug 23;229(4715):767-9. doi: 10.1126/science.3860954.

Abstract

The human c-mos proto-oncogene is located on chromosome 8 at band q22, close to the breakpoint in the t(8;21) (q22;q22) chromosome rearrangement. This translocation is associated with acute myeloblastic leukemia, subgroup M2. The c-myc gene, another proto-oncogene, has been mapped to 8q24. The breakpoint at 8q22 separates these genes, as determined by in situ hybridization of c-mos and c-myc probes. The c-mos gene remains on the 8q-chromosome and the c-myc gene is translocated to the 21q+ chromosome. Southern blot analysis of DNA from bone marrow cells of four patients with this translocation showed no rearrangement of c-mos.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosome Mapping
  • Chromosomes, Human, 21-22 and Y*
  • Chromosomes, Human, 6-12 and X*
  • Humans
  • Leukemia, Myeloid, Acute / genetics*
  • Nucleic Acid Hybridization
  • Oncogenes*
  • Proto-Oncogene Mas
  • Translocation, Genetic*