A role for nNOS in mediating stress and female sexual behavior in mice

Nat Commun. 2024 Apr 30;15(1):3609. doi: 10.1038/s41467-024-47993-z.

Abstract

Developmental stress can detrimentally affect adult female reproductive behavior, influencing sexual receptivity and fertility. Recent work has demonstrated neuronal nitric oxide (NO) synthase (nNOS)-promoted NO release in the ventromedial hypothalamus as a nexus between pre-pubertal stress and adult sexual behavior in mice.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Female
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Nitric Oxide Synthase Type I* / genetics
  • Nitric Oxide Synthase Type I* / metabolism
  • Sexual Behavior, Animal* / physiology
  • Stress, Psychological* / metabolism

Substances

  • Nitric Oxide Synthase Type I
  • Nos1 protein, mouse