Abstract
A series of diabetic patients from 3 centres in South India have been tested for HLA A, HLA B, BF, C2, C4A, C4B and GLO types. For insulin-dependent diabetes mellitus (IDDM) patients there was a significant increase in HLA B8, of BF F and decrease of C4 A6. No significant variation in HLA, BF, C2 or GLO frequencies was found in non-insulin-dependent diabetes mellitus (NIDDM) patients, but there was a significant decrease in C4B 1 and an increase in C4B 2. The HLA and BF association in South Indian IDDM patients is very different from that reported previously in North India.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Adult
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Child
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Child, Preschool
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Chromosomes, Human, 6-12 and X
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Complement C2 / analysis*
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Complement C2 / genetics
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Complement C4 / analysis*
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Complement C4 / genetics
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Complement C4a
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Complement C4b
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Complement Factor B / genetics*
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Diabetes Mellitus, Type 1 / epidemiology
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Diabetes Mellitus, Type 1 / genetics*
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Diabetes Mellitus, Type 1 / immunology
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Diabetes Mellitus, Type 2 / epidemiology
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Diabetes Mellitus, Type 2 / genetics*
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Diabetes Mellitus, Type 2 / immunology
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Enzyme Precursors / genetics*
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Gene Frequency
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HLA Antigens / analysis*
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HLA-A Antigens
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HLA-B Antigens
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Humans
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India
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Infant
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Infant, Newborn
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Lactoylglutathione Lyase / genetics*
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Lyases / genetics*
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Phenotype
Substances
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Complement C2
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Complement C4
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Enzyme Precursors
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HLA Antigens
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HLA-A Antigens
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HLA-B Antigens
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Complement C4a
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Complement C4b
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Complement Factor B
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Lyases
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Lactoylglutathione Lyase