Abstract
PHA-activated lymphocyte supernatants and high doses of affinity-purified human gamma-interferon enhance the expression of apparently normal Class I histocompatibility antigens in a malignant human trophoblast cell line that expresses low amounts of these antigens under normal culture conditions. Another human choriocarcinoma cell line, Jar, which is normally HLA-, did not respond to this treatment. This system provides a model in which to study further the regulation and effects of MHC antigen expression in cells of trophoblastic origin.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antibodies, Monoclonal
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Antigens, Surface / analysis
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Antigens, Surface / immunology
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Binding Sites, Antibody
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Cell Line
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Choriocarcinoma / genetics
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Choriocarcinoma / immunology*
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Female
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Fluorescent Antibody Technique
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HLA Antigens / analysis*
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HLA Antigens / immunology
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Humans
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Interferon-gamma / pharmacology*
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Lymphocyte Activation / drug effects
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Phenotype
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Precipitin Tests
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Pregnancy
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Uterine Neoplasms / genetics
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Uterine Neoplasms / immunology*
Substances
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Antibodies, Monoclonal
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Antigens, Surface
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HLA Antigens
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Interferon-gamma