Abstract
The authors describe two sisters who presented with a clinical picture consistent with mania. On further investigation, both had marked vermian and cerebellar cortical atrophy on CAT scans. Their mother also had a history suggestive of cerebellar disease. To the authors' knowledge, this is the first report of familial cerebellar disease with a clinical presentation of mania.
MeSH terms
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Adult
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Atrophy
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Bipolar Disorder / diagnosis
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Bipolar Disorder / etiology
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Bipolar Disorder / genetics*
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Cerebellar Diseases / complications
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Cerebellar Diseases / diagnostic imaging
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Cerebellar Diseases / genetics*
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Cerebellum / diagnostic imaging
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Female
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Humans
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Neurocognitive Disorders / diagnosis
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Neurocognitive Disorders / etiology
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Neurocognitive Disorders / genetics
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Tomography, X-Ray Computed