Plasmenylethanolamine: growth factor for cholesterol-reducing Eubacterium

J Bacteriol. 1979 Sep;139(3):755-60. doi: 10.1128/jb.139.3.755-760.1979.

Abstract

A plasmalogen, plasmenylethanolamine, is required for in vitro growth of strains of Eubacterium which convert cholesterol to coprostanol. Plasmenylethanolamine was isolated from calf brain by selective saponification of lipid fractions separated by thin-layer or column chromatography. Cholesterol-containing thioglycolate broth plus purified plasmenylethanolamine or its 2-lyso derivative supported growth of Eubacterium ATCC 21408 and a cholesterol-reducing Eubacterium isolated from baboon feces. Plasmenylethanolamine obtained from commercial sources also supported growth of these organisms, but none of a number of other pure lipids would support growth. Metabolism of the alkenyl ether group of plasmenylethanolamine occurred during growth.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cholesterol / metabolism*
  • Eubacterium / drug effects
  • Eubacterium / growth & development
  • Eubacterium / metabolism*
  • Kinetics
  • Plasmalogens / pharmacology*

Substances

  • Plasmalogens
  • phosphatidal ethanolamines
  • Cholesterol