Abstract
4 patients with presumed pituitary hypothalamic sarcoidosis are described. 3 had histological diagnoses compatible with sarcoidosis and in the other this diagnosis was strongly suspected from chest X-rays. 2 patients presented with diabetes insipidus. ACTH reserve was diminished in 3 out of 4 and growth hormone reserve was diminished in the 3 who were tested. All 4 patients developed secondary amenorrhea. 3 patients had hypothalamic hypothyroidism. Prolactin dynamics were intact. Tomograms of the sella turcica in all 4 and computerized tomography of the hypothalamic area in 2 patients failed to reveal any abnormality.
Publication types
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Case Reports
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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17-Hydroxycorticosteroids / urine
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Adolescent
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Adrenocorticotropic Hormone
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Adult
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Female
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Gonadotropin-Releasing Hormone
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Growth Hormone / blood
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Humans
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Hydrocortisone / blood
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Hydroxysteroids / urine
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Hypoglycemia / chemically induced
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Hypopituitarism / metabolism*
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Hypothalamo-Hypophyseal System / physiopathology*
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Insulin
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Luteinizing Hormone / blood
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Metyrapone
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Middle Aged
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Prolactin / blood
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Sarcoidosis / metabolism*
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Thyrotropin / blood
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Thyrotropin-Releasing Hormone
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Vasopressins / blood
Substances
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17-Hydroxycorticosteroids
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Hydroxysteroids
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Insulin
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Vasopressins
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Gonadotropin-Releasing Hormone
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Thyrotropin-Releasing Hormone
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Adrenocorticotropic Hormone
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Prolactin
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Luteinizing Hormone
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Thyrotropin
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Growth Hormone
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Hydrocortisone
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Metyrapone