Abstract
A tissue-specific transcriptional enhancer element that is associated with the human immunoglobulin heavy-chain locus is defined. In a non-Hodgkin's lymphoma that contains a translocated c-myc gene this enhancer is retained on the 14q+ chromosome and occurs within sequences shown to activate previously cryptic promoters of the c-myc gene.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Base Sequence
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Gene Expression Regulation*
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Genes, Regulator*
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Humans
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Immunoglobulin Heavy Chains / genetics*
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Lymphoma / genetics
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RNA, Messenger / biosynthesis
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Transcription, Genetic*
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Translocation, Genetic
Substances
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Immunoglobulin Heavy Chains
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RNA, Messenger
Associated data
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GENBANK/K01901
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GENBANK/K01907