A pericentric inversion of chromosome 16 is associated with dysplastic marrow eosinophils in acute myelomonocytic leukemia

Blood. 1984 Apr;63(4):800-2.

Abstract

Cytogenetic studies were performed in 18 consecutive children with acute nonlymphocytic leukemia (ANLL) between 1981 and 1983. Three children with acute myelomonocytic leukemia (AMMoL; M4, FAB classification) had the following unique bone marrow morphology and cytogenetic abnormality: eosinophilic precursors with dysplastic violaceous granules and a pericentric inversion of chromosome 16. Surface marker analysis of leukemic cells from these patients, using a panel of monoclonal antibodies, revealed the expression of a series of monocyte markers. The association of an inversion of chromosome 16 with abnormal eosinophil morphology in the M4 subtype of ANLL appears to represent a unique subgroup of patients.

MeSH terms

  • Bone Marrow / ultrastructure*
  • Child
  • Chromosome Aberrations / blood
  • Chromosome Aberrations / diagnosis*
  • Chromosome Aberrations / pathology
  • Chromosome Banding
  • Chromosome Disorders
  • Chromosomes, Human, 16-18*
  • Cytoplasmic Granules / pathology
  • Eosinophils / ultrastructure*
  • Humans
  • Infant
  • Leukemia, Myeloid, Acute / blood
  • Leukemia, Myeloid, Acute / genetics*
  • Leukemia, Myeloid, Acute / pathology
  • Male