Abstract
To investigate the possible contribution of genetic susceptibility to Kaposi's sarcoma associated with acquired immune deficiency syndrome (AIDS-KS), 21 patients were typed for HLA-A, B, C, and DR antigens. Significantly increased frequencies of HLA-Aw23, and HLA-Bw49 antigens were observed in the Caucasian AIDS-KS group. In this same group, the frequencies of HLA-DR5 and HLA-Bw44 antigens were increased at the P less than 0.1 level. Increased frequencies of HLA-A29 and HLA-Cw4 antigens and a decreased frequency of HLA-B8 antigen were also noted, but with P greater than 0.1, in the Caucasian AIDS-KS group.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acquired Immunodeficiency Syndrome / complications
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Acquired Immunodeficiency Syndrome / genetics*
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Acquired Immunodeficiency Syndrome / immunology
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Disease Susceptibility
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Ethnicity
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HLA Antigens / immunology*
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HLA-A Antigens
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HLA-B Antigens
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HLA-C Antigens
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HLA-DR Antigens
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Histocompatibility Antigens Class II / immunology
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Humans
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Phenotype
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Sarcoma, Kaposi / complications
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Sarcoma, Kaposi / genetics*
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Sarcoma, Kaposi / immunology
Substances
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HLA Antigens
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HLA-A Antigens
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HLA-B Antigens
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HLA-C Antigens
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HLA-DR Antigens
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Histocompatibility Antigens Class II